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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GYS1
All Species:
21.21
Human Site:
T458
Identified Species:
33.33
UniProt:
P13807
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13807
NP_002094.2
737
83786
T458
D
S
S
D
P
I
L
T
T
I
R
R
I
G
L
Chimpanzee
Pan troglodytes
XP_520790
703
80912
S434
I
M
K
R
A
I
F
S
T
Q
R
Q
S
L
P
Rhesus Macaque
Macaca mulatta
Q8MJ26
737
83768
T458
D
S
S
D
P
I
L
T
T
I
R
R
I
G
L
Dog
Lupus familis
XP_534869
703
80957
S434
I
M
K
R
A
I
F
S
T
Q
R
Q
S
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1E4
738
83908
T458
D
S
S
D
P
I
L
T
T
I
R
R
I
G
L
Rat
Rattus norvegicus
A2RRU1
738
84053
T458
D
S
S
D
P
I
L
T
T
I
R
R
I
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505471
733
83148
T458
D
S
S
D
P
I
L
T
T
I
R
R
I
G
L
Chicken
Gallus gallus
XP_416432
704
81032
I433
I
T
I
M
K
R
A
I
F
S
T
Q
R
H
C
Frog
Xenopus laevis
NP_001084863
702
80811
I433
V
T
I
M
K
R
A
I
F
A
T
Q
R
Q
S
Zebra Danio
Brachydanio rerio
NP_957474
700
80455
I432
F
T
M
M
K
R
A
I
F
A
T
Q
R
Q
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFC8
709
81735
K433
N
V
Q
Q
A
V
G
K
R
M
F
D
T
C
L
Honey Bee
Apis mellifera
XP_624707
692
79590
G423
M
Y
E
M
C
L
S
G
R
M
P
D
V
Q
D
Nematode Worm
Caenorhab. elegans
Q9U2D9
672
76441
Q405
N
V
E
S
L
K
G
Q
A
V
T
K
Q
L
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23337
708
80492
P441
R
P
Y
G
E
L
P
P
V
V
T
H
N
M
C
Red Bread Mold
Neurospora crassa
O93869
706
80888
L439
P
I
V
T
H
N
M
L
N
D
H
E
D
P
I
Conservation
Percent
Protein Identity:
100
68.6
99
69.3
N.A.
96.6
96.6
N.A.
90
71
69.3
78.1
N.A.
55
56.4
49.6
N.A.
Protein Similarity:
100
81.8
99.5
82.5
N.A.
98.5
98.5
N.A.
95.2
84.1
82.5
86.5
N.A.
71
70.1
65.8
N.A.
P-Site Identity:
100
20
100
20
N.A.
100
100
N.A.
100
0
0
0
N.A.
6.6
0
0
N.A.
P-Site Similarity:
100
33.3
100
33.3
N.A.
100
100
N.A.
100
13.3
13.3
13.3
N.A.
26.6
20
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
50
51.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
67.1
67
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
20
0
20
0
7
14
0
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
20
% C
% Asp:
34
0
0
34
0
0
0
0
0
7
0
14
7
0
7
% D
% Glu:
0
0
14
0
7
0
0
0
0
0
0
7
0
0
0
% E
% Phe:
7
0
0
0
0
0
14
0
20
0
7
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
14
7
0
0
0
0
0
34
0
% G
% His:
0
0
0
0
7
0
0
0
0
0
7
7
0
7
0
% H
% Ile:
20
7
14
0
0
47
0
20
0
34
0
0
34
0
7
% I
% Lys:
0
0
14
0
20
7
0
7
0
0
0
7
0
0
7
% K
% Leu:
0
0
0
0
7
14
34
7
0
0
0
0
0
20
40
% L
% Met:
7
14
7
27
0
0
7
0
0
14
0
0
0
7
0
% M
% Asn:
14
0
0
0
0
7
0
0
7
0
0
0
7
0
0
% N
% Pro:
7
7
0
0
34
0
7
7
0
0
7
0
0
7
14
% P
% Gln:
0
0
7
7
0
0
0
7
0
14
0
34
7
20
0
% Q
% Arg:
7
0
0
14
0
20
0
0
14
0
47
34
20
0
0
% R
% Ser:
0
34
34
7
0
0
7
14
0
7
0
0
14
0
7
% S
% Thr:
0
20
0
7
0
0
0
34
47
0
34
0
7
0
0
% T
% Val:
7
14
7
0
0
7
0
0
7
14
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _